Jon Swain
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Thompson Sampling

  • Nov 26, 2025 • 17 min read

    Working with Large Virtual Chemical Libraries: Part 3 - Thompson Sampling for Classification

    Exhaustively screening billion-compound virtual libraries would take decades, so we need smarter ways to hunt for molecules. I look at how we can adapt Thompson Sampling, a classic reinforcement learning technique, using the Beta distribution to efficiently find active compounds without breaking our computers.

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I am a data scientist and cheminformatician, originally from the UK, but often found in Aotearoa (New Zealand). I'm interested in using data science and machine learning to solve problems in drug discovery. When not in front of a computer, I can usually be found in the mountains or on the water.